Introduction Cancer causes an impact in the face of its news, whether due to feelings of anguish, stress and suffering due to the presence of the disease, which can be shared between patients, family members and loved ones.The news regarding the diagnosis generates, in addition to the psychological impact, financial difficulties, as the patient him
Modeling Mycobacterium tuberculosis early granuloma formation in experimental human lung tissue
The widely used animal models for tuberculosis (TB) display fundamental differences from human TB.Therefore, a validated model that recapitulates human lung TB is attractive for TB research.Here, we describe a unique method for establishment of TB infection in an experimental human lung tissue model.The model is based on cell lines derived from hum
Attenuation by l-thyroxine of oxidant-induced gut epithelial damage
Objective(s): Severe injuries are often associated with tissue hypothyroidism, elevated damaging mediators in circulation, and broken gut epithelial barrier.However, the relationships between the hypothyroid state and gut epithelial damage are largely unknown.Therefore, in this study, we investigated the effects of L-thyroxine (T4) on in vitro mode